Earth imaging with microsatellites: An investigation, design, implementation and in-orbit demonstration of electronic imaging systems for earth observation on-board low-cost microsatellites.

This research programme has studied the possibilities and difficulties of using 50 kg microsatellites to perform remote imaging of the Earth. The design constraints of these missions are quite different to those encountered in larger, conventional spacecraft. While the main attractions of microsatellites are low cost and fast response times, they present the following key limitations: Payload mass under 5 kg, Continuous payload power under 5 Watts, peak power up to 15 Watts, Narrow communications bandwidths (9.6 / 38.4 kbps), Attitude control to within 5°, No moving mechanics. The most significant factor is the limited attitude stability. Without sub-degree attitude control, conventional scanning imaging systems cannot preserve scene geometry, and are therefore poorly suited to current microsatellite capabilities. The foremost conclusion of this thesis is that electronic cameras, which capture entire scenes in a single operation, must be used to overcome the effects of the satellite's motion. The potential applications of electronic cameras, including microsatellite remote sensing, have erupted with the recent availability of high sensitivity field-array CCD (charge-coupled device) image sensors. The research programme has established suitable techniques and architectures necessary for CCD sensors, cameras and entire imaging systems to fulfil scientific/commercial remote sensing despite the difficult conditions on microsatellites. The author has refined these theories by designing, building and exploiting in-orbit five generations of electronic cameras. The major objective of meteorological scale imaging was conclusively demonstrated by the Earth imaging camera flown on the UoSAT-5 spacecraft in 1991. Improved cameras have since been carried by the KITSAT-1 (1992) and PoSAT-1 (1993) microsatellites. PoSAT-1 also flies a medium resolution camera (200 metres) which (despite complete success) has highlighted certain limitations of microsatellites for high resolution remote sensing. A reworked, and extensively modularised, design has been developed for the four camera systems deployed on the FASat-Alfa mission (1995). Based on the success of these missions, this thesis presents many recommendations for the design of microsatellite imaging systems. The novelty of this research programme has been the principle of designing practical camera systems to fit on an existing, highly restrictive, satellite platform, rather than conceiving a fictitious small satellite to support a high performance scanning imager. This pragmatic approach has resulted in the first incontestable demonstrations of the feasibility of remote sensing of the Earth from inexpensive microsatellites

Kevoree Modeling Framework (KMF): Efficient modeling techniques for runtime use

The creation of Domain Specific Languages(DSL) counts as one of the main goals in the field of Model-Driven Software Engineering (MDSE). The main purpose of these DSLs is to facilitate the manipulation of domain specific concepts, by providing developers with specific tools for their domain of expertise. A natural approach to create DSLs is to reuse existing modeling standards and tools. In this area, the Eclipse Modeling Framework (EMF) has rapidly become the defacto standard in the MDSE for building Domain Specific Languages (DSL) and tools based on generative techniques. However, the use of EMF generated tools in domains like Internet of Things (IoT), Cloud Computing or Models@Runtime reaches several limitations. In this paper, we identify several properties the generated tools must comply with to be usable in other domains than desktop-based software systems. We then challenge EMF on these properties and describe our approach to overcome the limitations. Our approach, implemented in the Kevoree Modeling Framework (KMF), is finally evaluated according to the identified properties and compared to EMF.Comment: ISBN 978-2-87971-131-7; N° TR-SnT-2014-11 (2014

Kevoree (Model@Runtime pour le développement continu de systèmes adaptatifs distribués hétérogènes)

La complexité croissante des systèmes d'information modernes a motivé l'apparition de nouveaux paradigmes (objets, composants, services, etc), permettant de mieux appréhender et maîtriser la masse critique de leurs fonctionnalités. Ces systèmes sont construits de façon modulaire et adaptable afin de minimiser les temps d'arrêts dus aux évolutions ou à la maintenance de ceux-ci. Afin de garantir des propriétés non fonctionnelles (par ex. maintien du temps de réponse malgré un nombre croissant de requêtes), ces systèmes sont également amenés à être distribués sur différentes ressources de calcul (grilles). Outre l'apport en puissance de calcul, la distribution peut également intervenir pour distribuer une tâche sur des nœuds aux propriétés spécifiques. C'est le cas dans le cas des terminaux mobiles proches des utilisateurs ou encore des objets et capteurs connectés proches physiquement du contexte de mesure. L'adaptation d'un système et de ses ressources nécessite cependant une connaissance de son état courant afin d'adapter son architecture et sa topologie aux nouveaux besoins. Un nouvel état doit ensuite être propagé à l'ensemble des nœuds de calcul. Le maintien de la cohérence et le partage de cet état est rendu particulièrement difficile à cause des connexions sporadiques inhérentes à la distribution, pouvant amener des sous-systèmes à diverger. En réponse à ces défi scientifiques, cette thèse propose une abstraction de conception et de déploiement pour systèmes distribués dynamiquement adaptables, grâce au principe du Model@Runtime. Cette approche propose la construction d'une couche de réflexion distribuée qui permet la manipulation abstraite de systèmes répartis sur des nœuds hétérogènes. En outre, cette contribution introduit dans la modélisation des systèmes adaptables la notion de cohérence variable, permettant ainsi de capturer la divergence des nœuds de calcul dans leur propre conception. Cette couche de réflexion, désormais cohérente "à terme", permet d'envisager la construction de systèmes adaptatifs hétérogènes, regroupant des nœuds mobiles et embarqués dont la connectivité peut être intermittente. Cette contribution a été concrétisée par un projet nommé ''Kevoree'' dont la validation démontre l'applicabilité de l'approche proposée pour des cas d'usages aussi hétérogènes qu'un réseau de capteurs ou une flotte de terminaux mobiles.The growing complexity of modern IT systems has motivated the development of new paradigms (objects, components, services,...) to better cope with the critical size of their functionalities. Such systems are then built as a modular and dynamically adaptable compositions, allowing them to minimise their down-times while performing evolutions or fixes. In order to ensure non-functional properties (i.e. request latency) such systems are distributed across different computation nodes. Besides the added value in term of computational power (cloud), this distribution can also target nodes with dedicated properties such as mobile nodes and sensors (internet of things), physically close to users for interactions. Adapting a system requires knowledge about its current state in order to adapt its architecture to its evolving needs. A new state must be then disseminated to other nodes to synchronise them. Maintaining its consistency and sharing this state is a difficult task especially in case of sporadic connexions which lead to divergent state between sub-systems. To tackle these scientific problems, this thesis proposes an abstraction to design and deploy distributed adaptive systems following the Model@Runtime paradigm. From this abstraction, the proposed approach allows defining a distributed reflexive layer to manipulate heterogeneous distributed nodes. In particular, this contribution introduces variable consistencies in model definition and divergence in system conception. This reflexive layer, eventually consistent allows the construction of distributed adapted systems even on mobile nodes with intermittent connectivity. This work has been realized in an open source project named Kevoree, and validated on various distributed systems ranging from sensor networks to cloud computing.RENNES1-Bibl. électronique (352382106) / SudocSudocFranceF

Integrating IoT and IoS with a Component-Based approach

International audienceThere is a growing interest in leveraging Service Oriented Architectures (SOA) in domains such as home automation, automotive, mobile phones or e-Health. With the basic idea (supported in e.g. OSGi) that components provide services, it makes it possible to smoothly integrate the Internet of Things (IoT) with the Internet of Services (IoS). The paradigm of the IoS indeed offers interesting capabilities in terms of dynamicity and interoperability. However in domains that involve ``things'' (e.g. appliances), there is still a strong need for loose coupling and a proper separation between types and instances that are well-known in Component-Based approaches but that typical SOA fail to provide. This paper presents how we can still get the best of both worlds by augmenting SOA with a Component-Based approach. We illustrate our approach with a case study from the domain of home automation

Early T Cell Signalling Is Reversibly Altered in PD-1+ T Lymphocytes Infiltrating Human Tumors

To improve cancer immunotherapy, a better understanding of the weak efficiency of tumor-infiltrating T lymphocytes (TIL) is necessary. We have analyzed the functional state of human TIL immediately after resection of three types of tumors (NSCLC, melanoma and RCC). Several signalling pathways (calcium, phosphorylation of ERK and Akt) and cytokine secretion are affected to different extents in TIL, and show a partial spontaneous recovery within a few hours in culture. The global result is an anergy that is quite distinct from clonal anergy induced in vitro, and closer to adaptive tolerance in mice. PD-1 (programmed death -1) is systematically expressed by TIL and may contribute to their anergy by its mere expression, and not only when it interacts with its ligands PD-L1 or PD-L2, which are not expressed by every tumor. Indeed, the TCR-induced calcium and ERK responses were reduced in peripheral blood T cells transfected with PD-1. Inhibition by sodium stibogluconate of the SHP-1 and SHP-2 phosphatases that associate with several inhibitory receptors including PD-1, relieves part of the anergy apparent in TIL or in PD-1-transfected T cells. This work highlights some of the molecular modifications contributing to functional defects of human TIL

Hox Paralog Group 2 Genes Control the Migration of Mouse Pontine Neurons through Slit-Robo Signaling

The pontine neurons (PN) represent a major source of mossy fiber projections to the cerebellum. During mouse hindbrain development, PN migrate tangentially and sequentially along both the anteroposterior (AP) and dorsoventral (DV) axes. Unlike DV migration, which is controlled by the Netrin-1/Dcc attractive pathway, little is known about the molecular mechanisms guiding PN migration along the AP axis. Here, we show that Hoxa2 and Hoxb2 are required both intrinsically and extrinsically to maintain normal AP migration of subsets of PN, by preventing their premature ventral attraction towards the midline. Moreover, the migration defects observed in Hoxa2 and Hoxb2 mutant mice were phenocopied in compound Robo1;Robo2, Slit1;Slit2, and Robo2;Slit2 knockout animals, indicating that these guidance molecules act downstream of Hox genes to control PN migration. Indeed, using chromatin immunoprecipitation assays, we further demonstrated that Robo2 is a direct target of Hoxa2 in vivo and that maintenance of high Robo and Slit expression levels was impaired in Hoxa2 mutant mice. Lastly, the analysis of Phox2b-deficient mice indicated that the facial motor nucleus is a major Slit signaling source required to prevent premature ventral migration of PN. These findings provide novel insights into the molecular control of neuronal migration from transcription factor to regulation of guidance receptor and ligand expression. Specifically, they address the question of how exposure to multiple guidance cues along the AP and DV axes is regulated at the transcriptional level and in turn translated into stereotyped migratory responses during tangential migration of neurons in the developing mammalian brain